Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event.
Nat Immunol
; 2(1): 51-7, 2001 Jan.
Article
em En
| MEDLINE
| ID: mdl-11135578
ABSTRACT
Lipopolysaccharide (LPS) induction of the gene encoding interleukin 12 p40 requires remodeling of a promoter-encompassing nucleosome and the Toll-like receptor (TLR)-mediated activation of a c-Rel-containing complex. Analysis of TLR4-mutant mice revealed that remodeling requires TLR signaling. However, Rel proteins and other proteins required for transcription of an integrated p40 promoter were insufficient for remodeling. c-Rel was also unnecessary for remodeling, as remodeling was observed in c-Rel-/- macrophages, which lack p40 transcripts. These results suggest that remodeling requires TLR signaling pathways that diverge from the c-Rel activation pathways. The factors that stimulate remodeling may represent, therefore, newly identified targets of TLR signaling and of agents that regulate inflammatory responses and TH1 development.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Nucleossomos
/
Regiões Promotoras Genéticas
/
Receptores de Superfície Celular
/
Interleucina-12
/
Proteínas de Drosophila
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Nat Immunol
Ano de publicação:
2001
Tipo de documento:
Article