Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease.
Neurology
; 56(1): 127-9, 2001 Jan 09.
Article
em En
| MEDLINE
| ID: mdl-11148253
ABSTRACT
The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to 1) cases had a 25% loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Proteínas de Ligação ao Cálcio
/
Glicoproteínas de Membrana
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Doença de Alzheimer
/
Proteínas do Tecido Nervoso
Limite:
Aged
/
Aged80
/
Humans
Idioma:
En
Revista:
Neurology
Ano de publicação:
2001
Tipo de documento:
Article