Selected contribution: effect of chronic passive length change on airway smooth muscle length-tension relationship.
J Appl Physiol (1985)
; 90(2): 734-40, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11160076
ABSTRACT
The ability of rabbit trachealis to undergo plastic adaptation to chronic shortening or lengthening was assessed by setting the muscle preparations at three lengths for 24 h in relaxed state a reference length in which applied force was approximately 1-2% of maximal active force (P(o)) and lengths considerably shorter and longer than the reference. Passive and active length-tension (L-T) curves for the preparations were then obtained by electrical field stimulation at progressively increasing muscle length. Classically shaped L-T curves were obtained with a distinct optimal length (L(o)) at which P(o) developed; however, both the active and passive L-T curves were shifted, whereas P(o) remained unchanged. L(o) was 72% and 148% that of the reference preparations for the passively shortened and lengthened muscles, respectively. The results suggest that chronic narrowing of the airways could induce a shift in the L-T relationship of smooth muscle, resulting in a maintained potential for maximal force production.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adaptação Fisiológica
/
Pulmão
/
Contração Muscular
/
Músculo Liso
Limite:
Animals
Idioma:
En
Revista:
J Appl Physiol (1985)
Ano de publicação:
2001
Tipo de documento:
Article