Relationship of follicle numbers and estradiol levels to multiple implantation in 3,608 intrauterine insemination cycles.
Fertil Steril
; 75(1): 69-78, 2001 Jan.
Article
em En
| MEDLINE
| ID: mdl-11163819
ABSTRACT
OBJECTIVE:
To determine the relationship of follicle numbers and estradiol (E(2)) levels to multiple implantations in human menopausal gonadotropin (hMG) and clomiphene citrate (CC) cycles.DESIGN:
Fifteen-year prospective study.SETTING:
Private infertility clinic. PATIENT(S) Women who underwent 3608 cycles of husband or donor intrauterine insemination (IUI). INTERVENTION(S) Ovulation induction (OI) with CC, hMG, or CC+hMG. MAIN OUTCOME MEASURE(S) Pregnancy and multiple implantations. RESULT(S) Triplet and higher-order implantations-but not twin implantations-were related to age, E(2) levels, and number of follicles > or = 12 mm and > or = 15 mm, but not number of follicles > or = 18 mm, in hMG and CC+hMG cycles. For patients less than 35 years old, three or more implantations tripled when six or more follicles were > or = 12 mm, in CC, hMG, and CC+hMG cycles, and when E(2) was > or = 1000 pg mL in hMG and CC+hMG cycles. For patients 35 or older, pregnancy rates in hMG and CC+hMG cycles doubled when six or more follicles were > or = 12 mm, or E(2) levels were >1000 pg mL, whereas 3 or more implantations were not significantly increased.CONCLUSIONS:
Withholding hCG or IUI in CC, hMG, and CC+hMG cycles when six or more follicles are > or = 12 mm may reduce triplet and higher-order implantations by 67% without significantly reducing pregnancy rates for patients under 35 years of age.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inseminação Artificial
/
Estradiol
/
Fármacos para a Fertilidade Feminina
/
Folículo Ovariano
/
Menotropinas
Tipo de estudo:
Etiology_studies
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Fertil Steril
Ano de publicação:
2001
Tipo de documento:
Article