Increase in plasma levels of oxidized low-density lipoproteins in patients with coronary spastic angina.
Atherosclerosis
; 154(2): 463-7, 2001 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-11166780
ABSTRACT
Oxidized low-density lipoproteins (LDL) impair endothelium-dependent dilation and constrict arteries. This study examined possible relation of the circulating plasma levels of Ox-LDL to coronary spastic angina (CSA). The plasma levels of Ox-LDL were measured by ELISA in 37 consecutive patients with CSA and normal coronary angiograms and in 79 consecutive control patients. The Ox-LDL levels in patients with CSA were significantly higher than those in controls. In multivariate analysis, higher levels of Ox-LDL were a risk factor for CSA independently of other traditional risk factors. The Ox-LDL levels had a significant and positive correlation with constrictor response of coronary arteries to the intracoronary acetylcholine infusion. Thus, Ox-LDL may play a possible role in pathogenesis of coronary spasm.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxirredução
/
Angina Pectoris Variante
/
Lipoproteínas LDL
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Atherosclerosis
Ano de publicação:
2001
Tipo de documento:
Article