Selective inhibition of amine oxidases differently potentiate the hypophagic effect of benzylamine in mice.
Eur J Pharmacol
; 413(1): 91-9, 2001 Feb 09.
Article
em En
| MEDLINE
| ID: mdl-11173067
ABSTRACT
In mice deprived of food for 12 h, the i.c.v. or i.p. administration of benzylamine, a substrate common to both monoamine oxidase B and semicarbazide-sensitive benzylamine oxidases, dose-dependently inhibited feeding. This effect was significantly potentiated by selective monoamine oxidase A and B inhibition, suggesting that central monoamines, known to be substrates of these enzymes may be released. The i.p. administration of semicarbazide-sensitive benzylamine oxidase inhibitors, B24 (3,5-ethoxy-4-aminomethylpyridine) and MDL 72274 ((E)-2-phenyl-3-chloroallylamine) strongly potentiated the effect of i.p. but not i.c.v.-administered benzylamine. The hypophagic effect of benzylamine was evaluated following i.c.v. administration, in comparison with the effect of the sympathomimetic compound amphetamine or the K(+) channel blocker tetraethylammonium, as reference compounds. Our results make it possible to define benzylamine as a centrally acting hypophagic compound devoid of amphetamine-like motor stimulatory effects and point to a role of B24 and MDL 72274 as specific peripheral enhancers of the pharmacological effects of benzylamine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzilaminas
/
Comportamento Alimentar
/
Monoaminoxidase
/
Inibidores da Monoaminoxidase
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2001
Tipo de documento:
Article