Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis.
Arthritis Res
; 3(1): 41-7, 2001.
Article
em En
| MEDLINE
| ID: mdl-11178125
ABSTRACT
The present study demonstrates that endogenous production of IL-12 is crucial for survival in Staphylococcus aureus-induced arthritis in mice. Staphylococcal load is enhanced in several organs, because of lack of IL-12. This might be due to decreased production of IFN-gamma in IL-12-deficient mice. Although IL-12-deficient mice were exposed to higher staphylococcal load, they demonstrated no increased severity of arthritis as compared with control animals.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Estafilocócicas
/
Artrite Infecciosa
/
Sepse
/
Interleucina-12
Limite:
Animals
Idioma:
En
Revista:
Arthritis Res
Ano de publicação:
2001
Tipo de documento:
Article