Hepatic iron deposition on MR imaging in patients with chronic liver disease: correlation with serial serum ferritin concentration.
Abdom Imaging
; 26(2): 149-56, 2001.
Article
em En
| MEDLINE
| ID: mdl-11178691
ABSTRACT
BACKGROUND:
To evaluate the relationship between magnetic resonance (MR) imaging grading of iron deposition and serial serum ferritin concentration in patients with chronic viral liver diseases.METHODS:
In 80 patients with viral hepatitis and cirrhosis, MR images including T2*-weighted gradient echo images (echo time > or = 6.5 ms) were reviewed. The grades of parenchymal iron deposition and iron-containing nodules in the liver and spleen and the liver-to-muscle and spleen-to-muscle signal intensity ratios were compared with the most recent, the mean, the lowest, and the highest values from all available serum ferritin levels.RESULTS:
The serum ferritin concentration was significantly correlated with the grades of iron deposition in liver and spleen and with the grades of iron-containing nodules seen on MR images (p < 0.05). Liver-to-muscle signal intensity ratio was weakly correlated with the ferritin concentrations. Among categories of ferritin concentration, correlation with MR grades was highest for mean ferritin concentration (r = 0.487, p < 0.001).CONCLUSION:
MR imaging grades of hepatic iron and siderotic nodules correlate with serum ferritin, especially with the mean levels.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Ferritinas
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Hepatite Viral Humana
/
Ferro
/
Fígado
/
Cirrose Hepática
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Abdom Imaging
Ano de publicação:
2001
Tipo de documento:
Article