Irinotecan in preoperative combined-modality therapy for locally advanced rectal cancer.
Oncology (Williston Park)
; 14(12 Suppl 14): 56-9, 2000 Dec.
Article
em En
| MEDLINE
| ID: mdl-11200151
ABSTRACT
Irinotecan (CPT-11, Camptosar) is a semisynthetic water-soluble derivative of the plant alkaloid camptothecin. This review will focus on the potential use of irinotecan in combination with fluorouracil (5-FU) in the preoperative combined-modality treatment of advanced rectal cancer. The laboratory studies that define the mechanism of fluoropyrimidine- and camptothecin-mediated radiosensitization are discussed, and the rationale for combined-modality therapy using radiation with 5-FU and irinotecan is presented.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Retais
/
Camptotecina
/
Protocolos de Quimioterapia Combinada Antineoplásica
Limite:
Humans
Idioma:
En
Revista:
Oncology (Williston Park)
Ano de publicação:
2000
Tipo de documento:
Article