Atherosclerotic plaques: classification and characterization with T2-weighted high-spatial-resolution MR imaging-- an in vitro study.
Radiology
; 219(2): 403-10, 2001 May.
Article
em En
| MEDLINE
| ID: mdl-11323464
ABSTRACT
PURPOSE:
To evaluate if T2-weighted high-spatial-resolution magnetic resonance (MR) imaging (117 microm per pixel) can help accurate classification of atherosclerotic plaques. MATERIALS ANDMETHODS:
Thirty human arteries and 11 carotid endarterectomy specimens from 31 patients underwent T2-weighted MR imaging (2-T magnet; repetition time, 2,000 msec; echo time, 50 msec) at room temperature. After imaging, Bouin fixative was used to fix 26 arteries, and the other 15 arteries were fixed by means of freezing. Specimens were stained with hematoxylin-eosin and safranin or Sudan lipid stain. MR images and histologic slices were classified independently by two radiologists and a pathologist, respectively, on the basis of the American Heart Association classification.RESULTS:
Results with MR imaging were the following type I-II plaques, sensitivity of 67% and specificity of 100%; type IV-Va plaques, sensitivity of 74% and specificity of 85%; type Vb plaques, sensitivity of 90% and specificity of 100%; type Vc plaques, sensitivity of 80% and specificity of 90%. No type III plaque was diagnosed in the study. The overall kappa value was 0.68.CONCLUSION:
High-spatial-resolution MR imaging with T2 weighting alone can help accurate classification of fibrocalcic plaques (type Vb), but it is subject to limitations for the classification and analysis of other types of atherosclerotic plaques.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artérias
/
Arteriosclerose
/
Imageamento por Ressonância Magnética
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Radiology
Ano de publicação:
2001
Tipo de documento:
Article