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Long man-made fibers and lung cancer risk.
Moolgavkar, S H; Turim, J; Brown, R C; Luebeck, E G.
Afiliação
  • Moolgavkar SH; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, MP 665, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
Regul Toxicol Pharmacol ; 33(2): 138-46, 2001 Apr.
Article em En | MEDLINE | ID: mdl-11350196
ABSTRACT
We show that available experimental data from long-term oncogenicity experiments in Fisher rats are consistent with the hypothesis that the oncogenic potential of long man-made mineral fibers is determined mainly by their biopersistence. We present analyses of these data within the initiation-promotion-progression paradigm of carcinogenesis. Our method of analysis can take the temporal pattern of the burden of long fibers in the lungs of individual animals into explicit account. For this analysis, the temporal pattern of lung burden for each animal was imputed from the information obtained from sacrificed animals. The data are consistent with the hypothesis that fibers act as initiators in the rat lung. We present an estimate of the dose-dependent initiation parameter that is based on all the available data.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transformação Celular Neoplásica / Fibras Minerais / Neoplasias Pulmonares / Manufaturas Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2001 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transformação Celular Neoplásica / Fibras Minerais / Neoplasias Pulmonares / Manufaturas Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2001 Tipo de documento: Article