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The alveolar septal thickness and type II pneumocytes number in irradiated lungs, time expression and the effect of pentoxifylline.
Osterreicher, J; Mokry, J; Navrátil, L; Knízek, J; Vávrová, J; Skopek, J; Macela, A.
Afiliação
  • Osterreicher J; Department of Radiobiology and Immunology, Purkyne Military Medical Academy, Hradec Králové. osterreicher@pmfhk.cz
Acta Medica (Hradec Kralove) ; 44(1): 15-9, 2001.
Article em En | MEDLINE | ID: mdl-11367886
PURPOSE: We studied the relationship between type II pneumocytes number and alveolar septal thickness during different time after sublethal whole-thorax irradiation of rats and we investigated the influence of pentoxifylline (TNF-alpha inhibitor). MATERIALS AND METHODS: Wistar rats were exposed to 15 Gy thoracic irradiation and pentoxifylline (35 mg/kg) twice a week. Lungs were examined histologically and immunohistochemically at intervals ranging from 1-12 weeks and alveolar septal thickness, number of type II pneumocytes (identified by immunoreactivity for cytokeratin 18), and neutrophile granulocytes were counted. RESULTS: Significant increase of alveolar septal thickness and type II pneumocytes depletion 3 weeks after irradiation were found. Correlation of these markers was r = -0.759. Pentoxifylline significantly inhibits increased alveolar septal thickness without the influence on type II pneumocytes number. Neutrophil penetration started 5 weeks after irradiation in non-treated animals, 8 weeks after irradiation in PTX-treated rats. CONCLUSIONS: We suggest that pneumocytes depletion is linked to increased vascular permeability, and pentoxifylline therapy does not influence on pneumocytes kinetics after irradiation.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pentoxifilina / Alvéolos Pulmonares / Vasodilatadores / Pulmão Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Medica (Hradec Kralove) Ano de publicação: 2001 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pentoxifilina / Alvéolos Pulmonares / Vasodilatadores / Pulmão Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Medica (Hradec Kralove) Ano de publicação: 2001 Tipo de documento: Article