Mononeuropathy multiplex as the initial manifestation of neurofibromatosis type 2.
Neurology
; 56(12): 1766-8, 2001 Jun 26.
Article
em En
| MEDLINE
| ID: mdl-11425952
ABSTRACT
The authors report a patient with neurofibromatosis type 2 (NF2) presenting with an axonal mononeuropathy multiplex. Sural nerve biopsy showed small scattered groups of Schwann cells transformed into irregular branching cells with abnormal cell-cell contacts. The authors hypothesize that defective Schwann cell function, due to inactivation of the NF2 gene product merlin, leads to changes in morphology, cell-cell contact, and growth, and finally to degeneration of axons.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neurofibromatose 2
/
Doenças do Sistema Nervoso Periférico
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Neurology
Ano de publicação:
2001
Tipo de documento:
Article