Heat shock proteins, HSP25 and HSP70, and apoptosis in developing endocardial cushion of the mouse heart.
Histochem Cell Biol
; 115(2): 95-104, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11444152
ABSTRACT
Formation of the atrioventricular channels and valves from the endocardial cushion occurs through growth and remodeling of the initial endocardial cushion. This process requires balanced coordination of proliferation and apoptosis by still unknown factors. To detect a possible role for the heat shock proteins 25 and 70 (HSP25 and HSP70) as apoptosis-associated proteins and differentiation factors in the development of the endocardial cushion, we analyzed their temporal and regional occurrence during cell proliferation and apoptosis in E11-E17 embryos. The distribution and timing of these events and factors were consistent with the hypothesis that HSP25 is related to myocardial development whereas HSP70 is related to differentiation of the endocardial cushion by cell proliferation and apoptosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apoptose
/
Proteínas de Choque Térmico HSP70
/
Endocárdio
/
Proteínas de Choque Térmico
/
Proteínas de Neoplasias
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Histochem Cell Biol
Ano de publicação:
2001
Tipo de documento:
Article