Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats.
Am J Physiol Regul Integr Comp Physiol
; 281(2): R444-51, 2001 Aug.
Article
em En
| MEDLINE
| ID: mdl-11448846
ABSTRACT
Melanocortins play a critical role in appetite and body weight regulation, because manipulations of this pathway can lead to the development of obesity in several animal models. The purpose of this study was to use a melanocortin receptor agonist and antagonist to evaluate the involvement of melanocortins in feeding, energy metabolism, and body weight regulation in lean and obese Zucker rats. Central administration of a melanocortin receptor antagonist (SHU9119) elevated food intake and body weight of lean Zucker rats but had little effect in obese Zucker rats. In contrast, the melanocortin receptor agonist MTII reduced food intake in both lean and obese rats but was more potent in the obese Zucker rats. These data indicate the existence of functional melanocortin receptors in both lean and obese Zucker rats but suggest that obese Zucker rats have reduced endogenous melanocortin tone. In addition to its effects on food intake, MTII infusion elevated oxygen consumption and decreased respiratory quotient dose dependently during the light cycle. Our data suggest that a melanocortin receptor agonist can induce weight loss by increasing energy expenditure and promoting body fat utilization in addition to its inhibitory effects on food intake in both obese and lean Zucker rats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ingestão de Energia
/
Hormônios Estimuladores de Melanócitos
/
Receptores da Corticotropina
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Metabolismo Energético
/
Obesidade
Tipo de estudo:
Health_economic_evaluation
Limite:
Animals
Idioma:
En
Revista:
Am J Physiol Regul Integr Comp Physiol
Ano de publicação:
2001
Tipo de documento:
Article