Pharmacokinetics of alizapride in children receiving chemotherapy for solid tumour.
Fundam Clin Pharmacol
; 15(3): 217-20, 2001 Jun.
Article
em En
| MEDLINE
| ID: mdl-11468033
ABSTRACT
The purpose of the present study was to determine the pharmacokinetics of alizapride to optimize its use in children aged 1 month to 15 years old who were receiving chemotherapy. Seventeen children were given a single 4 mg/kg alizapride infusion prior to the administration of cytostatic drugs. Blood and urine samples were collected within 10 h after onset of the infusion. Kinetic parameters were calculated and showed a decrease in plasma clearance expressed per unit of body weight with age. The current data suggest that dosage expressed per unit of body weight should be higher in children than in adults and higher in infants than in children.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
Antieméticos
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Fundam Clin Pharmacol
Ano de publicação:
2001
Tipo de documento:
Article