Dextromethorphan affects cocaine-mediated behavioral pattern in parallel with a long-lasting Fos-related antigen-immunoreactivity.
Life Sci
; 69(6): 615-24, 2001 Jun 29.
Article
em En
| MEDLINE
| ID: mdl-11476183
ABSTRACT
In order to understand the underlying mechanisms responsible for the behaviors mediated by dextromethorphan (DM), we examined the effects of DM on locomotor activity and locomotor patterns in mice, and Fos-related antigen immunoreactivity (FRA-IR) of mouse brain following repeated administration of cocaine. Combined treatments (30 min prior to each cocaine administration) with DM dose-dependently decreased locomotor activity for high doses of cocaine (20 mg/kg, i.p./day x 7). DM combinations did not significantly affect hyperactivity for 10 mg cocaine/kg, i.p./day x 7. In contrast, combined treatments with DM increased the locomotor activity for 5 mg cocaine/kg, i.p./day x 7. These results were consistent with alterations in marginal activity. Repeated administration with cocaine or DM increased FRA-IR in the nucleus accumbens (NAc) and striatum which lasted for at least 7 days. Our results suggest that DM exhibits biphasic effects on the locomotor stimulation induced by cocaine, and that locomotor activities are in parallel with FRA-IR of the striatal complex. However, the role of FRA-IR regulated by DM or/and cocaine remains to be further determined.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antitussígenos
/
Comportamento Animal
/
Encéfalo
/
Proteínas Proto-Oncogênicas c-fos
/
Cocaína
/
Dextrometorfano
/
Atividade Motora
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
2001
Tipo de documento:
Article