Atrial natriuretic peptide mimetics and vasopeptidase inhibitors.
Cardiovasc Res
; 51(3): 416-28, 2001 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-11476732
ABSTRACT
There is now substantial evidence supporting a role of the natriuretic peptides as a major defence mechanism against excess salt and water retention and high blood pressure. Because of this there has been considerable interest in the therapeutic potential of the natriuretic peptide system. Several approaches have been explored including the use of native peptides, the development of natriuretic peptides mimetics and targetting of endogenous clearance of natriuretic peptides. While ANP and BNP administration may be valuable in some circumstances, however, the limitations of the use of peptides especially for long-term treatment are well apparent. In view of this, considerable effort has been devoted to the development of orally active agents to enhance endogenous natriuretic peptides through inhibition of breakdown by neutral endopeptidase. This research has now led to the vasopeptidase inhibitors - dual inhibitors of both endopeptidase and angiotensin converting enzyme. These agents clearly provide a novel approach to enhance endogenous natriuretic peptide function on a background of reduced angiotensin II activity and may lead to an important advance in the treatment of hypertension and of conditions associated with overt salt and water overload.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteases
/
Inibidores da Enzima Conversora de Angiotensina
/
Doenças Cardiovasculares
/
Fator Natriurético Atrial
Limite:
Humans
Idioma:
En
Revista:
Cardiovasc Res
Ano de publicação:
2001
Tipo de documento:
Article