Influence of age on activities of antioxidant enzymes and lipid peroxidation products in erythrocytes and neutrophils of Down syndrome patients.
Free Radic Biol Med
; 31(4): 499-508, 2001 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-11498283
ABSTRACT
Thirty-seven individuals with Down syndrome (DS) were divided into four age categories (i) 1 to < 6 years, (ii) 6 to < 13 years, (iii) 13 to < 20 years, and (iv) over 20 years. Activities of antioxidant enzymes found in individual age categories were different, but the differences between age groups were not statistically significant. We confirmed significantly higher activities of Cu/Zn superoxide dismutase (SOD) and glutathione peroxidase (GPx) in blood cells of people with DS as compared to 35 controls, which consisted, for the first time, of siblings of children with DS. No significant differences were found in activities of catalase and glutathione reductase in DS vs. controls. A significant difference was observed in serum concentration of malondialdehyde (MDA) in DS vs. controls (8.39 +/- 0.34 micromol/l vs. 7.34 +/- 0.27 micromol/l; p = .021) and concentration of MDA in erythrocytes of individuals with DS between the third and fourth age group (p = .05). In DS persons, an elevated ratio of SOD to catalase plus GPx with respect to the controls in all age categories was found, suggesting oxidative imbalance, potentially contributing to accelerated aging observed in these persons.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases
/
Envelhecimento
/
Catalase
/
Síndrome de Down
/
Eritrócitos
/
Peróxidos Lipídicos
/
Neutrófilos
Limite:
Adolescent
/
Adult
/
Child
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Child, preschool
/
Humans
/
Infant
Idioma:
En
Revista:
Free Radic Biol Med
Ano de publicação:
2001
Tipo de documento:
Article