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Salivary HCV-antibodies; a follow-up cohort study of liver disease patients.
Elsana, S; Sikuler, E; Yaari, A; Shemer-Avni, Y; Margalith, M.
Afiliação
  • Elsana S; Department of Virology, Soroka Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Clin Lab ; 47(7-8): 335-8, 2001.
Article em En | MEDLINE | ID: mdl-11499794
We have recently shown in Liver Clinic patients that saliva instead of serum may be used for anti-HCV detection. As compared to blood withdrawing, saliva is easier to obtain, non invasive, especially for infants. In the present study, sequential determination of serum and salivary anti-HCV was performed in the same cohort for 36 months. Anti-HCV seropositive and seronegative patients were studied. Blood and saliva samples were obtained simultaneously. From the anti-HCV seronegative patients (n=33), 161 sequential serum and 161 matched saliva samples were obtained. All were anti-HCV negative. From the anti-HCV seropositive patients (n=35), 131 sequential serum and 131 matched saliva samples were obtained. All sequential serum samples were anti-HCV positive. Of the saliva samples 126 (96%) were anti-HCV positive and five (4%) were anti-HCV negative. These five samples were obtained from two patients with autoimmune hepatitis and HCV-RNA seronegative by PCR. The results suggest that saliva may serve as a substitute for serum for the detection of anti-HCV antibodies.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saliva / Hepacivirus / Hepatopatias / Anticorpos Antivirais Tipo de estudo: Diagnostic_studies / Etiology_studies / Evaluation_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Clin Lab Ano de publicação: 2001 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saliva / Hepacivirus / Hepatopatias / Anticorpos Antivirais Tipo de estudo: Diagnostic_studies / Etiology_studies / Evaluation_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Clin Lab Ano de publicação: 2001 Tipo de documento: Article