Idiopathic short stature.
J Pediatr Endocrinol Metab
; 14 Suppl 2: 967-74, 2001 Jul.
Article
em En
| MEDLINE
| ID: mdl-11529403
Idiopathic short stature (ISS) is a term used to describe the status of children with short stature that cannot be attributed to a specific cause. Many children diagnosed as having ISS have partial GH insensitivity, which can result from disturbances at various points of the GH-IGF-I axis. Several clinical studies on spontaneous growth in ISS showed that adult height was almost in the range of target height. GH treatment led to adult height not significantly higher than the pretreatment predicted adult height in most reports. No metabolic side effects have been observed, even when the dose was higher than in GH deficiency. Manipulation of puberty with gonadotrophin releasing hormone analogues reported by a few authors in a small number of children has shown conflicting results. Long-term psychological benefits of GH therapy for short normal children have not been demonstrated to date.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estatura
/
Transtornos do Crescimento
Tipo de estudo:
Etiology_studies
/
Guideline
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Pediatr Endocrinol Metab
Ano de publicação:
2001
Tipo de documento:
Article