Biological activity of complexes derived from thiophene-2-carbaldehyde thiosemicarbazone. Crystal structure of [Ni(C(6)H(6)N(3)S(2))(2)].
J Inorg Biochem
; 86(2-3): 627-33, 2001 Sep.
Article
em En
| MEDLINE
| ID: mdl-11566336
ABSTRACT
The crystal structure of [Ni(L(III))(2)] (1), where HL(III)=thiophene-2-carbaldehyde thiosemicarbazone, consists of monomeric entities where the nickel(II) ions exhibit distorted square planar geometry. The two bidentate thiosemicarbazone ligands are centrosymmetric. C...S van der Waals' links and nonbonded intramolecular interactions are present in the structure. The biological activity of 1 is compared to that of the free ligand, and the cobalt(III) (2) and copper(II) (3) derivatives. The observed order of cytotoxicity against melanoma B16F10 and Friend erythroleukemia cells is 1< or =ligand<2<3. A structure-activity correlation using Extended-Hückel MO calculations is described.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Tiofenos
/
Tiossemicarbazonas
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Revista:
J Inorg Biochem
Ano de publicação:
2001
Tipo de documento:
Article