Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease.
Brain Res
; 914(1-2): 48-56, 2001 Sep 28.
Article
em En
| MEDLINE
| ID: mdl-11578596
ABSTRACT
The main objective of this study was to determine if levels of alpha-, beta- and/or gamma-synuclein mRNAs are differentially affected in brains of Lewy body disease (LBD) and Alzheimer's disease (AD) patients, compared to controls. In control cases, highest levels of expression were observed in the neocortex and the lowest in basal ganglia and substantia nigra. beta-Synuclein was the most abundant message (75-80%), followed by gamma-synuclein (10-15%) and alpha-synuclein (8-10%). Analysis of the superior temporal cortex, a region selectively affected in LBD and AD, showed that compared to controls, levels of alpha-synuclein were increased in cases of diffuse LBD (DLBD), levels of beta-synuclein were decreased in AD and DLBD, and levels of gamma-synuclein were increased in AD cases. This study suggests that a critical balance among products of the synuclein gene is important to maintain normal brain function and that alterations in this balance might be associated with neurodegenerative disorders.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
RNA Mensageiro
/
Expressão Gênica
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Doença por Corpos de Lewy
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Doença de Alzheimer
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Proteínas do Tecido Nervoso
Limite:
Aged
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Humans
Idioma:
En
Revista:
Brain Res
Ano de publicação:
2001
Tipo de documento:
Article