Molecular neurobiology of addiction.
Am J Addict
; 10(3): 201-17, 2001.
Article
em En
| MEDLINE
| ID: mdl-11579619
ABSTRACT
Addiction can be viewed as a form of drug-induced neural plasticity. One of the best established molecular mechanisms of addiction is the upregulation of the cAMP second messenger pathway, which occurs in many neuronal cell types in response to chronic administration of opiates or other drugs of abuse. This upregulation and the resulting activation of the transcription factor CREB appear to mediate aspects of tolerance and dependence. In contrast, induction of another transcription factor, termed delta FosB, exerts the opposite effect and may contribute to sensitized responses to drug exposure. Knowledge of these mechanisms could lead to more effective treatments for addictive disorders.
Buscar no Google
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Transtornos Relacionados ao Uso de Substâncias
Limite:
Humans
Idioma:
En
Revista:
Am J Addict
Ano de publicação:
2001
Tipo de documento:
Article