Anticonvulsant activities of ethanolic extract and aqueous fraction isolated from Delphinium denudatum.
J Ethnopharmacol
; 78(1): 73-8, 2001 Nov.
Article
em En
| MEDLINE
| ID: mdl-11585691
ABSTRACT
Dried roots of Delphinium denudatum Wall. are a popular folk remedy for the treatment of epilepsy in the traditional Unani system of medicine in the sub-continent. We carried out anticonvulsant screening of the ethanolic extract (EE) and aqueous fraction (AF) of this plant utilising the maximal electroshock (MEST) and subcutaneous pentylenetetrazole (scPTZ), bicuculline (scBIC), picrotoxin (scPTX) and strychnine (scSTN) tests for anticonvulsant activity. EE had weak dose-dependent anticonvulsant effects on seizures induced by PTZ and BIC. AF exhibited dose-dependent activity against hind limb tonic extension phase (HLTE) of MEST and comparatively stronger anticonvulsant activity against seizures induced by PTZ and BIC. The results suggest the presence of potent anticonvulsant compounds in AF of D. denudatum and deserve further investigation for isolation of active compounds and elucidation of the mechanism of anticonvulsant action.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ranunculaceae
/
Anticonvulsivantes
Limite:
Animals
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2001
Tipo de documento:
Article