Relationship between beta-cell responsiveness and fasting plasma glucose in Caucasian subjects with newly presenting type 2 diabetes.
Diabet Med
; 18(10): 797-802, 2001 Oct.
Article
em En
| MEDLINE
| ID: mdl-11678969
ABSTRACT
AIMS:
beta-cell responsiveness was related to fasting plasma glucose to gain further understanding of pathophysiology of Type 2 diabetes.METHODS:
An insulin secretion model gave fasting beta-cell responsiveness M0 (ability of fasting glucose to stimulate beta-cell) and postprandial beta-cell responsiveness MI (ability of postprandial glucose to stimulate beta-cell) by analysing glucose and C-peptide time-concentration curves sampled every 10-30 min over 240 min during a meal tolerance test (MTT; 75 g CHO, 500 kcal). Caucasian subjects with newly presenting Type 2 diabetes according to WHO criteria (N = 83, male/female 65 18, age 54 +/- 10 years, body mass index (BMI) 30.9 +/- 5.2 kg/m2, fasting plasma glucose (FPG) 11.0 +/- 3.2 mmol/L; mean +/- SD) and Caucasian healthy subjects (N = 54, m/f 21 33, age 48 +/- 9 years, BMI 26.1 +/- 3.7 kg/m2, FPG 5.1 +/- 0.4 mmol/L) were studied.RESULTS:
A continuum inverse relationship between MI and FPG was observed. In the diabetes group, MI was closely related to FPG (rs = -0.74, P < 0.0001) and explained 60% intersubject FPG variability with the use of an exponential regression model.CONCLUSIONS:
In newly presenting Type 2 diabetes in Caucasian subjects a close inverse association exists between postprandial beta-cell responsiveness and FPG.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Peptídeo C
/
Ilhotas Pancreáticas
/
Diabetes Mellitus Tipo 2
/
Insulina
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Diabet Med
Ano de publicação:
2001
Tipo de documento:
Article