Effect of oleamide on sleep and its relationship to blood pressure, body temperature, and locomotor activity in rats.
Exp Neurol
; 172(1): 235-43, 2001 Nov.
Article
em En
| MEDLINE
| ID: mdl-11681856
ABSTRACT
Oleamide (cis-9,10-octadecenoamide) is a brain lipid that has recently been isolated from the cerebral fluid of sleep-deprived cats. Intracerebroventricular and intraperitoneal administration of oleamide induces sleep in rats. However, it is unclear whether oleamide's hypnogenic effects are mediated, in part, by its actions on blood pressure and core body temperature. Here we show that systemic administration of oleamide (10 and 20 mg/kg) in rats increased slow-wave sleep 2, without affecting blood pressure and heart rate. In addition, oleamide decreased body temperature and locomotor activity in a dose-dependent manner. These latter effects were not correlated in time with the observed increases in slow-wave sleep. These data suggest that the hypnogenic effects of oleamide are not related to changes in blood pressure, heart rate, or body temperature.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sono
/
Pressão Sanguínea
/
Temperatura Corporal
/
Ácidos Oleicos
/
Atividade Motora
Limite:
Animals
Idioma:
En
Revista:
Exp Neurol
Ano de publicação:
2001
Tipo de documento:
Article