The transcriptional co-activators CBP and p300 are activated via phenylephrine through the p42/p44 MAPK cascade.
J Biol Chem
; 277(4): 2517-24, 2002 Jan 25.
Article
em En
| MEDLINE
| ID: mdl-11705990
ABSTRACT
The CBP and p300 co-activators play a key role in many aspects of gene regulation being recruited to the DNA via transcription factors that are targets for specific signaling pathways. It has previously been demonstrated that in neuronal cells the ability of CBP and p300 to activate transcription can be directly stimulated by nerve growth factor or calcium-activated signaling pathways. Here we demonstrate that, in cardiac cells, the activity of CBP and p300 is stimulated by phenylephrine (PE) treatment and that they are required for the activation of atrial naturetic factor (ANF) gene expression by PE. Activation of CBP/p300 by PE involves the p42/p44 MAPK pathway and targets primarily the N terminus of p300 and the C terminus of CBP, which are not homologous to one another. To our knowledge, this is the first report of a specific stimulus modulating the activity of CBP and p300 in cardiac cells and it suggests that these factors play an important role in the hypertrophic effect of PE.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilefrina
/
Transcrição Gênica
/
Proteínas Nucleares
/
Transativadores
/
Proteína Quinase 1 Ativada por Mitógeno
/
Proteínas Quinases Ativadas por Mitógeno
Limite:
Animals
Idioma:
En
Revista:
J Biol Chem
Ano de publicação:
2002
Tipo de documento:
Article