Thromboxane A2 signalling in humans: a 'Tail' of two receptors.
Biochem Soc Trans
; 29(Pt 6): 641-54, 2001 Nov.
Article
em En
| MEDLINE
| ID: mdl-11709048
ABSTRACT
Since its discovery in 1975, we now have a wealth of knowledge relating to the biochemical, pharmacological and physiological actions of thromboxane A(2) (TXA(2)) and its related metabolites. These molecular insights have been greatly expedited by the molecular cloning and characterization of a cDNA for the human TXA(2) receptor, now termed the T Prostanoid or TP receptor, from a megakaryocytic/placental cDNA library in 1991, and later through the discovery of a cDNA encoding a second isoform of the human TP receptor in 1994. The requirement for two TP receptors in primates, but not in other species thus far investigated, is unclear, but points to potential species-specific physiological differences. In this review, I will describe some recent advances in the research field of TXA(2)/TP receptor signalling, focusing particularly on studies pertaining to the human TP receptor isoforms.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tromboxano A2
/
Transdução de Sinais
/
Receptores de Tromboxanos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Ano de publicação:
2001
Tipo de documento:
Article