Menstrual cyclic variation of myocardial ischemia in premenopausal women with variant angina.
Ann Intern Med
; 135(11): 977-81, 2001 Dec 04.
Article
em En
| MEDLINE
| ID: mdl-11730398
ABSTRACT
BACKGROUND:
An abundance of ovarian hormones is assumed to be a major contributor to the low incidence of ischemic heart disease in premenopausal women. However, the effects of ovarian hormones remain undetermined.OBJECTIVE:
To examine whether the variation in ovarian hormone levels throughout a menstrual cycle affects myocardial ischemia in women with variant angina.DESIGN:
Prospective, observational study.SETTING:
University medical center in Japan.PARTICIPANTS:
10 premenopausal women with variant angina. MEASUREMENTS Frequency of spontaneous ischemic episodes, flow-mediated dilation of brachial artery, and serum levels of estradiol and progesterone.RESULTS:
Frequency of ischemic episodes was highest from the end of the luteal phase to the beginning of the menstrual phase and was lowest in the follicular phase. Flow-mediated vasodilation and estradiol levels were lowest from the end of the luteal phase to the beginning of the menstrual phase and were highest in the follicular phase.CONCLUSIONS:
In premenopausal women with variant angina, we documented a cyclic variation in endothelial function and the frequency of myocardial ischemia that was associated with the variation in estrogen levels.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Progesterona
/
Isquemia Miocárdica
/
Estradiol
/
Angina Pectoris Variante
/
Ciclo Menstrual
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Ann Intern Med
Ano de publicação:
2001
Tipo de documento:
Article