Cholinergic deficits in the brains of patients with parkinsonism-dementia complex of Guam.
Neuroreport
; 12(18): 3901-3, 2001 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-11742207
ABSTRACT
Patients with parkinsonism-dementia complex (PDC) of Guam showed moderate loss of choline acetyl transferase activity in the midfrontal and inferior parietal cortex, and severe loss in the superior temporal cortex. This deficit was similar to that seen in Alzheimer's disease and less severe than Lewy body disease. Thus, cholinergic deficits in the neocortex might contribute to some of the cognitive alterations in PDC of Guam.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Colina O-Acetiltransferase
/
Neocórtex
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neuroreport
Ano de publicação:
2001
Tipo de documento:
Article