Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice.
Neurosci Lett
; 316(3): 145-8, 2001 Dec 28.
Article
em En
| MEDLINE
| ID: mdl-11744223
ABSTRACT
There is circumstantial evidence that the reelin signaling pathway may contribute to neurodegeneration in the adult brain and could be linked to Alzheimer's disease (AD). In the present immunohistochemical report we studied the reelin expression profile in double-transgenic mice that express both human mutant beta-amyloid precursor protein (APP) and human mutant presenilin-1. We were able to demonstrate that reelin immunostaining was found together with human APP in the neuritic component of many AD-typical plaques in both hippocampus and neocortex. This observation gives the first evidence for the association of reelin with amyloid deposits.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Moléculas de Adesão Celular Neuronais
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Córtex Cerebral
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Proteínas da Matriz Extracelular
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Precursor de Proteína beta-Amiloide
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Placa Amiloide
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Doença de Alzheimer
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Hipocampo
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Proteínas de Membrana
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2001
Tipo de documento:
Article