Influence of polymeric enteral nutrition supplemented with different doses of glutamine on gut permeability in critically ill patients.
Nutrition
; 17(11-12): 907-11, 2001.
Article
em En
| MEDLINE
| ID: mdl-11744338
ABSTRACT
OBJECTIVES:
To evaluate the effect of glutamine-supplemented polymeric enteral formulas on the recovery of gut-permeability abnormalities in critically ill patients.METHODS:
Twenty-three patients were randomized to receive a conventional casein-based enteral formula (ADN), ADN plus glutamine in a dose of 0.15 g x kg(-1) x d(-1) or ADN plus 0.30 g x kg(-1) x d(-1) of glutamine for 8 d. The lactulose mannitol permeability test (L/M) was performed at baseline and at the end of the study. Nineteen healthy volunteers served as controls for the L/M test.RESULTS:
An increase in permeability compared with control subjects was observed in patients at baseline (mean +/- standard error of the mean; L/M ratio 0.11 +/- 0.03 and 0.025 +/- 0.004, respectively; P < 0.02). The L/M ratio improved after the period of enteral nutrition as a whole (initial L/M 0.11 +/- 0.03, final L/M 0.061 +/- 0.01; P < 0.03), but no difference was found between groups.CONCLUSIONS:
Even though polymeric enteral nutrition was associated with a significant improvement in the L/M ratio, glutamine supplementation did not show a specific influence in improving recovery of gut permeability in critically ill patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alimentos Formulados
/
Estado Terminal
/
Nutrição Enteral
/
Glutamina
/
Mucosa Intestinal
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Nutrition
Ano de publicação:
2001
Tipo de documento:
Article