Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292.
Bioorg Med Chem Lett
; 12(2): 109-12, 2002 Jan 21.
Article
em En
| MEDLINE
| ID: mdl-11755332
ABSTRACT
Replacement of the 2-Adoc-D-alphaMeTrp residue in the non-selective CCK(1) receptor agonist PD 170292 by the Z-(2R,5R,11bS)-IBTM skeleton, able to fix a type II beta-turn-like conformation, led to a conformationally restricted dipeptoid analogue, namely 3a, which exhibited a notable increase in the CCK(1) selectivity and antagonist properties.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adamantano
/
Receptores da Colecistocinina
/
Citrulina
/
Mimetismo Molecular
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2002
Tipo de documento:
Article