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[Therapeutic application for the aged with CML].
Ohta, M.
Afiliação
  • Ohta M; Department of Hematology, Tokyo Metropolitan Geriatric Medical Center.
Nihon Rinsho ; 59(12): 2407-9, 2001 Dec.
Article em Ja | MEDLINE | ID: mdl-11766347
ABSTRACT
Therapeutic application for elderly CML patients had been restricted to use of alkylating or antimetabolite agents. In order to improve quality of life in the aged with CML interferon-alpha therapy is now first choice for treatment of elderly chronic phase of CML patients under appropriate informed consent. This treatment provided long term survival with cytological and cytogenetic responses even in the aged. In elderly patients attention has to be paid for the occurrence of side effects such as psychological changes. Further studies are on going in special reference to molecularly targeted therapy, i.e. a specific inhibitor of tyrosine kinase, or non-myeloablative stem cell transplantation.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Leucemia Mieloide de Fase Crônica / Consentimento Livre e Esclarecido Aspecto: Patient_preference Limite: Aged / Humans Idioma: Ja Revista: Nihon Rinsho Ano de publicação: 2001 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Leucemia Mieloide de Fase Crônica / Consentimento Livre e Esclarecido Aspecto: Patient_preference Limite: Aged / Humans Idioma: Ja Revista: Nihon Rinsho Ano de publicação: 2001 Tipo de documento: Article