Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris.
J Nat Prod
; 65(2): 95-9, 2002 Feb.
Article
em En
| MEDLINE
| ID: mdl-11858737
ABSTRACT
Fractionation of a methanol extract of the leaves and twigs of Casearia sylvestris, as directed by activity against KB cell cytotoxicity, led to the isolation of three novel clerodane diterpenoids, casearvestrins A-C (1-3). The structures of 1-3 were deduced from one- and two-dimensional NMR experiments, including relative stereochemical assignments based on ROESY correlations and COSY coupling constants. All three compounds displayed promising bioactivity, both in cytotoxicity assays against a panel of tumor cell lines and in antifungal assays via the growth inhibition of Aspergillus niger in a disk diffusion assay.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Magnoliopsida
/
Diterpenos
/
Antifúngicos
/
Antineoplásicos Fitogênicos
Limite:
Female
/
Humans
País/Região como assunto:
America do sul
/
Ecuador
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2002
Tipo de documento:
Article