Peroxynitrite-mediated stress is associated with proliferation of human metastatic colorectal carcinoma in the liver.
Cancer Lett
; 179(1): 87-93, 2002 May 08.
Article
em En
| MEDLINE
| ID: mdl-11880186
ABSTRACT
3-Nitrotyrosine (3-NT), a product of peroxynitrite reaction, is abundantly observed in hepatocytes adjacent to human metastatic colorectal carcinoma. To elucidate its biological significance, we undertook to identify nitric oxide (NO)-producing cells and apoptosis under oxidative stress. We observed strong inducible NO-synthase (iNOS) immunoreactivity in the hepatocytes adjacent to metastatic tumor, revealing an identical pattern to 3-NT immunostaining. Furthermore, intense 3-NT immunostaining of hepatocytes was associated with apoptosis whereas carcinoma cells near those hepatocytes presented high proliferating-cell nuclear antigen. Our results suggest that contact of metastatic tumor induces apoptosis in adjacent hepatocytes through peroxynitrite, thus permitting the proliferation of cancer cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tirosina
/
Neoplasias Colorretais
/
Adenocarcinoma
/
Oxidantes
/
Estresse Oxidativo
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Neoplasias Hepáticas
/
Nitratos
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
2002
Tipo de documento:
Article