Anatomic and functional characteristics of the rat ileal pouch.
Am J Surg
; 183(4): 464-70, 2002 Apr.
Article
em En
| MEDLINE
| ID: mdl-11975937
ABSTRACT
BACKGROUND:
The definitive operation for chronic ulcerative colitis (UC) and familial adenomatous polyposis is total proctocolectomy with ileal pouch-anal anastomosis (IPAA). Mild inflammation (pouchitis) is omnipresent in pouches and becomes severe in 50% of UC patients with IPAA. The etiology of pouchitis is likely due to combined genetic, microbial, and immunologic factors. Epithelial cell exposure to surgical trauma and/or to changes in intestinal bacterial composition may account for the inflammatory infiltrate. Progress in understanding pouchitis is restricted by the lack of suitable animal models.METHODS:
An ileal pouch-rectal anastomosis [IPRA] in rats was developed to reproduce a model of human IPAA and clinical, gross and histologic criteria were determined.RESULTS:
Many shared features with human ileal pouch were observed.CONCLUSION:
IPRA is an important in vivo model to study mechanisms of repair, defense and immunity that may contribute to pouchitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reto
/
Proctocolectomia Restauradora
/
Pouchite
/
Íleo
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Am J Surg
Ano de publicação:
2002
Tipo de documento:
Article