Atypical tentorial meningioma 30 years after radiotherapy for a pituitary adenoma.
Neurol Sci
; 22(6): 463-7, 2002 Mar.
Article
em En
| MEDLINE
| ID: mdl-11976979
ABSTRACT
Although the human central nervous system used to be considered relatively resistant to the carcinogenic action of ionizing radiation, several lines of evidence now document a high incidence of secondary tumors in irradiated patients. The numerous reports of radiation-induced cerebral meningiomas generally distinguish those induced by high-dose radiation from those induced by low-dose radiation. We describe the case of patient who underwent subtotal resection of a chromophobe pituitary adenoma at the age of 18 years, who was successively treated by conventional fractionated radiotherapy with gamma rays emitted by a source of 60Co until a total dose of 41 Gy. Over the next 30 years the patient experienced all the known late effects of radiation, including panhypopituitarism, cranial-nerve deficits (II, III and VI), massive radiation necrosis involving the left cerebral hemisphere and causing right hemiparesis and aphasia and, ultimately, an atypical tentorial meningioma with early recurrence after total resection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Hipofisárias
/
Adenoma Cromófobo
/
Neoplasias Cerebelares
/
Neoplasias Meníngeas
/
Meningioma
/
Neoplasias Induzidas por Radiação
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurol Sci
Ano de publicação:
2002
Tipo de documento:
Article