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Atypical tentorial meningioma 30 years after radiotherapy for a pituitary adenoma.
Santoro, A; Minniti, G; Paolini, S; Passacantilli, E; Missori, P; Frati, A; Cantore, G P.
Afiliação
  • Santoro A; Neurosurgery Unit I, Department of Neurological Sciences, La Sapienza University of Rome, Viale dell'Università 30a, Italy.
Neurol Sci ; 22(6): 463-7, 2002 Mar.
Article em En | MEDLINE | ID: mdl-11976979
ABSTRACT
Although the human central nervous system used to be considered relatively resistant to the carcinogenic action of ionizing radiation, several lines of evidence now document a high incidence of secondary tumors in irradiated patients. The numerous reports of radiation-induced cerebral meningiomas generally distinguish those induced by high-dose radiation from those induced by low-dose radiation. We describe the case of patient who underwent subtotal resection of a chromophobe pituitary adenoma at the age of 18 years, who was successively treated by conventional fractionated radiotherapy with gamma rays emitted by a source of 60Co until a total dose of 41 Gy. Over the next 30 years the patient experienced all the known late effects of radiation, including panhypopituitarism, cranial-nerve deficits (II, III and VI), massive radiation necrosis involving the left cerebral hemisphere and causing right hemiparesis and aphasia and, ultimately, an atypical tentorial meningioma with early recurrence after total resection.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Hipofisárias / Adenoma Cromófobo / Neoplasias Cerebelares / Neoplasias Meníngeas / Meningioma / Neoplasias Induzidas por Radiação Tipo de estudo: Diagnostic_studies Limite: Adolescent / Humans / Male / Middle aged Idioma: En Revista: Neurol Sci Ano de publicação: 2002 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Hipofisárias / Adenoma Cromófobo / Neoplasias Cerebelares / Neoplasias Meníngeas / Meningioma / Neoplasias Induzidas por Radiação Tipo de estudo: Diagnostic_studies Limite: Adolescent / Humans / Male / Middle aged Idioma: En Revista: Neurol Sci Ano de publicação: 2002 Tipo de documento: Article