[Bactericidal activity of biapenem against various efflux system mutants of Pseudomonas aeruginosa].
Jpn J Antibiot
; 55(1): 67-76, 2002 Feb.
Article
em Ja
| MEDLINE
| ID: mdl-11977922
ABSTRACT
The bactericidal activity of biapenem, a new carbapenem, against various efflux-mutants of Pseudomonas aeruginosa was compared with those of imipenem, panipenem, meropenem and ceftazidime. The bactericidal activity of biapenem against P. aeruginosa KG5001, a strain deficient in MexAB-OprM, MexCD-OprJ and MexXY-OprM, was very strong compared with those of imipenem and meropenem. In terms of bactericidal activities, biapenem and imipenem had similar activities against P. aeruginosa KG5003, a strain overexpressing MexAB-OprM, as against P. aeruginosa KG5001, however meropenem and ceftazidime had weaker activities against KG5003 than KG5001. The bactericidal activity against P. aeruginosa KG5007, a strain overexpressing MexCD-OprJ, was observed only by biapenem. The bactericidal activity of biapenem was strong and not influenced by all of these three efflux systems.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pseudomonas aeruginosa
/
Tienamicinas
/
Antibacterianos
Idioma:
Ja
Revista:
Jpn J Antibiot
Ano de publicação:
2002
Tipo de documento:
Article