Exon 1 polymorphism of the B2BKR gene does not influence the clinical status of patients with hereditary angioedema.
Hum Immunol
; 63(6): 492-4, 2002 Jun.
Article
em En
| MEDLINE
| ID: mdl-12039525
ABSTRACT
Polymorphic variants of B2 receptors for bradykinin (B2BKR) have been postulated to influence a clinical manifestation of hereditary angioedema. In this study, exon 1 nonanucleotide deletion polymorphism in the B2BKR gene was examined in 37 patients with hereditary angioedema. The patients were grouped according to disease severity or the age of the first clinical manifestation of disease. No significant differences in allelic frequencies were found between particular subgroups of patients. Therefore, we concluded that this polymorphism does not seem to have any significant effect on the course and severity of hereditary angioedema in Caucasians.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Éxons
/
Receptores da Bradicinina
/
Angioedema
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Hum Immunol
Ano de publicação:
2002
Tipo de documento:
Article