Brainstem involvement in Unverricht-Lundborg disease (EPM1): An MRI and (1)H MRS study.
Neurology
; 58(11): 1686-9, 2002 Jun 11.
Article
em En
| MEDLINE
| ID: mdl-12058102
ABSTRACT
MRI of the brain and proton MRS ((1)H MRS) of the pons and dentate were obtained in 10 patients with genetically confirmed Unverricht-Lundborg disease (EPM1) and 20 control subjects. Patients with EPM1 showed (p < or = 0.01) loss of bulk of the basis pontis, medulla, and cerebellar hemispheres. Cerebral atrophy was present in six patients. The N-acetylaspartate/creatine and choline/creatine ratios were reduced in the pons but not in the dentate (p < or = 0.005). Brainstem involvement could play a role in pathophysiology of EPM1.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tronco Encefálico
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Imageamento por Ressonância Magnética
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Espectroscopia de Ressonância Magnética
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Ácido Aspártico
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Síndrome de Unverricht-Lundborg
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Neurology
Ano de publicação:
2002
Tipo de documento:
Article