Gram-scale synthesis of (+)- and (-)-trans-10-amino-9-hydroxy-9,10-dihydrophenanthrene by enzymatic hydrolysis.
Chirality
; 14(6): 490-4, 2002 Jun.
Article
em En
| MEDLINE
| ID: mdl-12112343
The enzymatic resolution of (+/-)-trans-10-azido-9-acetoxy-9,10-dihydrophenanthrene by Candida cylindracea lipase-catalyzed hydrolysis was achieved on the gram-scale with excellent yield and enantiomeric excess. The resulting (+)- and (-)-amino alcohols were derivatized to alpha-hydroxy-N-benzenesulphonamides.
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MEDLINE
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En
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Chirality
Ano de publicação:
2002
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Article