Effects of aspirin on renal sodium excretion, blood pressure, and plasma and extracellular fluid volume in salt-loaded rats.
Prostaglandins
; 10(5): 825-31, 1975 Nov.
Article
em En
| MEDLINE
| ID: mdl-1215544
ABSTRACT
The effect of aspirin administration and presumed blockade of prostaglandin synthesis on renal sodium excretion, plasma and extracellular fluid volumes, and blood pressure were examined in rats on a high sodium intake. After acute salt loading aspirin treated rats showed an impaired sodium excretion, while no changes in glomerular filtration rate were observed. In chronically loaded rats (7 weeks) administration of aspirin induced significant increases in both plasma and extracellular fluid volume, but no significant changes in blood pressures were found. The results are consistent with the hypothesis that prostaglandins mediate renal sodium excretion and therefore participate in extracellular fluid volume regulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Volume Plasmático
/
Sódio
/
Pressão Sanguínea
/
Aspirina
/
Espaço Extracelular
Limite:
Animals
Idioma:
En
Revista:
Prostaglandins
Ano de publicação:
1975
Tipo de documento:
Article