Synthesis of novel water soluble benzylazolium prodrugs of lipophilic azole antifungals.
Bioorg Med Chem Lett
; 12(19): 2775-80, 2002 Oct 07.
Article
em En
| MEDLINE
| ID: mdl-12217374
ABSTRACT
Water soluble N-benzyltriazolium or N-benzylimidazolium salt type prodrugs of several highly lipophilic triazole or imidazole antifungals have been synthesized. They were designed to undergo an enzymatic activation followed by a self-cleavage to release a parent drug. The prodrugs such as 16 had enough chemical stability and water solubility for parenteral use and were rapidly and quantitatively converted to the active substance in human plasma.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azóis
/
Triazóis
/
Pró-Fármacos
/
Antifúngicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2002
Tipo de documento:
Article