HLA in Egyptian children with biliary atresia.

A-Kader, Hassan H; El-Ayyouti, Moustafa; Hawas, Samia; Abdalla, Ahmed; Al-Tonbary, Yousif; Bassiouny, Mohammed; Boneberg, Anna; El-Sallab, Shadia

A-Kader, Hassan H; El-Ayyouti, Moustafa; Hawas, Samia; Abdalla, Ahmed; Al-Tonbary, Yousif; Bassiouny, Mohammed; Boneberg, Anna; El-Sallab, Shadia.

Afiliação

A-Kader HH; Department of Pediatrics, Upstate Medical University, Syracuse, New York 13210, USA.

J Pediatr ; 141(3): 432-3, 2002 Sep.

Article em En | MEDLINE | ID: mdl-12219069

RESUMO

We studied the human leukocytes antigens in 18 Egyptian children with biliary atresia (BA) without extrahepatic congenital malformations. There was a significant increased frequency of both B8 and DR3 (83.3% and 94.4% in patients with BA compared with 6.5% and 14.9% in the general population, respectively). Ten patients had the B8/DR3 haplotype. Our results support the hypothesis that genetic factors may play a role in susceptibility to BA.

Assuntos

Atresia Biliar/imunologia; Antígenos HLA/sangue; Atresia Biliar/genética; Estudos de Casos e Controles; Criança; Pré-Escolar; Egito/epidemiologia; Feminino; Antígenos HLA/genética; Antígeno HLA-B8/sangue; Antígeno HLA-B8/genética; Antígeno HLA-DR3/sangue; Antígeno HLA-DR3/genética; Haplótipos; Humanos; Lactente; Masculino; Risco

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Atresia Biliar / Antígenos HLA Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: Africa Idioma: En Revista: J Pediatr Ano de publicação: 2002 Tipo de documento: Article

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