Ethical considerations concerning treatment allocation in drug development trials.
Stat Methods Med Res
; 11(5): 403-11, 2002 Oct.
Article
em En
| MEDLINE
| ID: mdl-12357586
ABSTRACT
It is claimed that much of the opposition to placebos is based on the misunderstanding that their use implies the withholding of effective treatments. It is also argued that the ethical feasibility of a trial must be judged by comparing the likely prognosis of patients in the trial to their expectations outside the trial. Furthermore, a longer-term perspective of the patients needs is necessary; the ethical dilemmas involved cannot be resolved at the point of sickness. Some device such as the 'original position' of the philosopher John Rawls is needed. Finally, it is argued that placebo run-ins involve a violation of consent and should be eliminated from clinical trials.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Defesa do Paciente
/
Distribuição Aleatória
/
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Seleção de Pacientes
/
Avaliação de Medicamentos
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Aspecto:
Ethics
Limite:
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Stat Methods Med Res
Ano de publicação:
2002
Tipo de documento:
Article