Efficient synthesis of a 4,5-epoxy-2-cyclohexen-1-one derivative bearing a spirolactone via a Diels-Alder reaction with high pi-facial selectivity: a synthetic study towards scyphostatin.

Takagi, Ryukichi; Miyanaga, Wataru; Tamura, Yukiko; Ohkata, Katsuo

Takagi, Ryukichi; Miyanaga, Wataru; Tamura, Yukiko; Ohkata, Katsuo.

Afiliação

Takagi R; Department of Chemistry, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan.

Chem Commun (Camb) ; (18): 2096-7, 2002 Sep 21.

Article em En | MEDLINE | ID: mdl-12357795

ABSTRACT

ABSTRACT

The Diels-Alder reaction of spirolactones with cyclopentadiene afforded the adduct with high pi-facial selectivity; a hydrophilic analogue of scyphostatin was synthesized from the Diels-Alder adduct.

Assuntos

Amidas/síntese química; Cicloexanonas/síntese química; Pironas/síntese química; Espironolactona/análogos & derivados; Espironolactona/síntese química

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pironas / Espironolactona / Cicloexanonas / Amidas Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2002 Tipo de documento: Article

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