Synthesis and structure-activity relationships of 2,3-benzodiazepines as AMPA receptor antagonists.
Mini Rev Med Chem
; 1(3): 243-53, 2001 Sep.
Article
em En
| MEDLINE
| ID: mdl-12369971
ABSTRACT
There is increasing evidence of the potential therapeutic utility of glutamate receptor antagonists in the treatment of several neurodegenerative disorders, including stroke and epilepsy. In the last few years noncompetitive AMPA receptor antagonists have received considerable attention due to their therapeutic potentiality. The discovery of GYKI 52466, the prototype of noncompetitive AMPA receptor antagonists endowed with anticonvulsant and neuroprotective properties, induced growing interest on 2,3-benzodiazepine derivatives. This review covers the chemistry and pharmacology of this important class of AMPA receptor antagonists.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ansiolíticos
/
Benzodiazepinas
/
Receptores de AMPA
/
Antagonistas de Aminoácidos Excitatórios
Limite:
Humans
Idioma:
En
Revista:
Mini Rev Med Chem
Ano de publicação:
2001
Tipo de documento:
Article