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Low-dose folic acid lowers plasma homocysteine levels in women of child-bearing age.
Daly, S; Mills, J L; Molloy, A M; Conley, M; McPartlin, J; Lee, Y J; Young, P B; Kirke, P N; Weir, D G; Scott, J M.
Afiliação
  • Daly S; Coombe Womens Hospital, Dublin, Ireland.
QJM ; 95(11): 733-40, 2002 Nov.
Article em En | MEDLINE | ID: mdl-12391385
ABSTRACT

BACKGROUND:

Ongoing clinical trials are investigating whether lowering plasma homocysteine reduces the risk of vascular disease. If so, food fortification with folic acid will be the likely result, and sub-optimal amounts are likely to be preferred, for safety reasons. Dose-finding studies are needed before the outcomes of these trials, to establish the benefits and risks of folic acid consumption over the widest intake range likely to be encountered.

AIM:

To find the lowest dose of folic acid that effectively reduces plasma homocysteine in premenopausal women.

DESIGN:

Double-blind, randomized placebo-controlled trial.

METHODS:

Women of child-bearing age (n=95) were randomly allocated to 0, 100, 200, or 400 microg/day of folic acid. Red-cell folate and plasma homocysteine were measured at baseline and after 10 weeks supplementation.

RESULTS:

Median red cell folate levels increased significantly in the 200 microg(p=0.0001) and 400 microg(p=0.0001) groups; but not in the placebo (0 microg) (p=0.25) or the 100 microg (p=0.5) groups. Only the 200 microg and the 400 microg groups had significant decreases in plasma homocysteine, (p=0.04 and p=0.0008, respectively). However, when subjects whose initial plasma homocysteine was <8 micromol/l (already optimally low) were removed from the analysis, there were significant plasma homocysteine decreases in all three treatment groups, but not the placebo group.

DISCUSSION:

In this sub-population, low doses of folic acid significantly lower plasma homocysteine. This could be achieved safely by fortification.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Fólico / Hematínicos / Homocisteína Tipo de estudo: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans Idioma: En Revista: QJM Ano de publicação: 2002 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Fólico / Hematínicos / Homocisteína Tipo de estudo: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans Idioma: En Revista: QJM Ano de publicação: 2002 Tipo de documento: Article